منابع مشابه
Airway smooth muscle and asthma.
The airway smooth muscle is the key determinant of airway narrowing in asthma but its function in the absence of disease is unknown. Evidence for an intrinsic abnormality in the muscle in asthma is only just emerging. The airway smooth muscle is not merely a contractile cell, but also one which determines the composition of, and interacts with the extracellular matrix, and which may participate...
متن کاملMechanotransduction, asthma, and airway smooth muscle.
Excessive force generation by airway smooth muscle is the main culprit in excessive airway narrowing during an asthma attack. The maximum force the airway smooth muscle can generate is exquisitely sensitive to muscle length fluctuations during breathing, and is governed by complex mechanotransduction events that can best be studied by a hybrid approach in which the airway wall is modeled in sil...
متن کاملAirway Smooth Muscle Hypercontractility in Asthma
In recent years, asthma has been defined primarily as an inflammatory disorder with emphasis on inflammation being the principle underlying pathophysiological characteristic driving airway obstruction and remodelling. Morphological abnormalities of asthmatic airway smooth muscle (ASM), the primary structure responsible for airway obstruction seen in asthma, have long been described, but surpris...
متن کاملAirway structural components drive airway smooth muscle remodeling in asthma.
Chronic asthma is an inflammatory airways disease characterized by pathological changes in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and hyperresponsiveness. Remodeling of the ASM is associated with an increased smooth muscle mass, involving components of cellular hypertrophy and hyperplasia, and changes in the phenotype of the muscle that facilitate proliferat...
متن کاملAsthma and sarcoplasmic reticulum Ca2+ reuptake in airway smooth muscle.
TO THE EDITOR: We were delighted to note the concurrent publication of two studies linking decreased expression and function of sarcoendoplasmic reticulum Ca ATPase (SERCA) in human airway (bronchial) smooth muscle (ASM) to asthma. The first study, published in the July 2009 issue of American Journal of Physiology Lung Molecular Cellular Physiology, was actually from our group (3), whereas the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Allergology International
سال: 2006
ISSN: 1323-8930
DOI: 10.2332/allergolint.55.215